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Sadly the All of Us program (of which I am a research subject [and researcher]) hasn't done any sort of imaging or ECG. They did draw blood, so that allowed for

Sadly the All of Us program (of which I am a research subject [and researcher]) hasn't done any sort of imaging or ECG. They did draw blood, so that allowed for genome sequencing. That may also, in principle, allow for assaying new biomarkers (I don't believe anything like that has been funded though).

westurner 2y ago
2009-2010 Meaningful Use criteria required physicians to implement electronic care records. There's now FHIR for sharing records between different vendors' EHR systems. There's a JSONLD representation of FHIR. Which health and exercise apps can generate FHIR for self-reporting? Can participants forward their other EHR/EMR records to the All of Us program? Can participants or Red Cross or other blood donation services forward collected vitals and sample screening data to the All of Us program?
- carbocation 2y ago
  The imaging reports are being imported, but not the images. The bigger issue is that clinical imaging is done due to medical indications. Medical indications dramatically confound the results. A key element of the UK Biobank's value is that imaging and ECG are being done without any clinical indication.
  - westurner 2y ago
    So they need more data from healthy patients when they're healthy in order to determine what's anomalous? SIEM tools do anomaly detection with lots of textual log data and sensor data. What would a Cost-effectiveness analysis say about collecting data from healthy patients: https://en.wikipedia.org/wiki/Cost-effectiveness_analysis https://en.wikipedia.org/wiki/Cost-effectiveness_analysis TIL the ROC curve applies to medical tests.
biomcgary 2y ago
Thanks for the insight! I have used UKB data extensively, but haven't seen much from All of US, so I was wondering if I had missed something. . .
- carbocation 2y ago
  All of Us is great for disease labels and for genetic validation (and discovery). I like it a lot. I just have... ideas for how they could make it more valuable. Ideas that I stole from Rory Collins. https://www.ukbiobank.ac.uk/media/gnkeyh2q/study-rationale.pdf https://www.ukbiobank.ac.uk/media/gnkeyh2q/study-rationale.p...

westurner 2y ago

2009-2010 Meaningful Use criteria required physicians to implement electronic care records. There's now FHIR for sharing records between different vendors' EHR systems. There's a JSONLD representation of FHIR. Which health and exercise apps can generate FHIR for self-reporting? Can participants forward their other EHR/EMR records to the All of Us program? Can participants or Red Cross or other blood donation services forward collected vitals and sample screening data to the All of Us program?

carbocation 2y ago
The imaging reports are being imported, but not the images. The bigger issue is that clinical imaging is done due to medical indications. Medical indications dramatically confound the results. A key element of the UK Biobank's value is that imaging and ECG are being done without any clinical indication.
- westurner 2y ago
  So they need more data from healthy patients when they're healthy in order to determine what's anomalous? SIEM tools do anomaly detection with lots of textual log data and sensor data. What would a Cost-effectiveness analysis say about collecting data from healthy patients: https://en.wikipedia.org/wiki/Cost-effectiveness_analysis https://en.wikipedia.org/wiki/Cost-effectiveness_analysis TIL the ROC curve applies to medical tests.

biomcgary 2y ago

Thanks for the insight! I have used UKB data extensively, but haven't seen much from All of US, so I was wondering if I had missed something. . .

carbocation 2y ago
All of Us is great for disease labels and for genetic validation (and discovery). I like it a lot. I just have... ideas for how they could make it more valuable. Ideas that I stole from Rory Collins. https://www.ukbiobank.ac.uk/media/gnkeyh2q/study-rationale.pdf https://www.ukbiobank.ac.uk/media/gnkeyh2q/study-rationale.p...