3 ms·

IMO GLP-1 agonists are obviously not free, from first principles. They might be for diabetics who carefully manage their diet, but many (most?) people using the

IMO GLP-1 agonists are obviously not free, from first principles. They might be for diabetics who carefully manage their diet, but many (most?) people using them for weight loss usually already have shitty diets with poor macronutrient balance and micronutrient deficiencies. Eating less of the crappy food they were eating before just makes the true situation worse. This is just the latest [1][2] evidence for the obvious muscle wasting that will happen to a human body that is starved of protein and micronutrients. The muscles under the skin are being cannibalized for protein that’s missing in the diet and other biochemical processes that restore them are starved of the nutrients they need to function. [1] https://news.ycombinator.com/item?id=37558780 https://news.ycombinator.com/item?id=37558780 [2] https://news.ycombinator.com/item?id=39326333 https://news.ycombinator.com/item?id=39326333

cameronh90 2y ago
Why do you think they just eat less of the same crappy food? In my experience, it turned down the reward feedback for calorie dense food, and I would usually now prefer something like a lentil daal over a Dominos.
- throwup238 2y ago
  Because GLP-1 agonists don't change anything other than the cravings and/or reward feedback. They don't add healthy menu items to existing restaurants, they don't put new grocery stores in food deserts, teach people how to shop for healthy food or how to cook it so it's palatable, or in any way mitigate any of the socioeconomic factors that drive people to eating unhealthy food. In my experience, the average American is looking at restaurants like McDonalds, Dominoes/PizzaHut, a local burger joint, and a "fancy" place like Olive Garden. They wouldn't be able to get something healthy like lentil daal if they wanted to, with the closest equivalent being a McDonald's salad.

cameronh90 2y ago

Why do you think they just eat less of the same crappy food? In my experience, it turned down the reward feedback for calorie dense food, and I would usually now prefer something like a lentil daal over a Dominos.

throwup238 2y ago
Because GLP-1 agonists don't change anything other than the cravings and/or reward feedback. They don't add healthy menu items to existing restaurants, they don't put new grocery stores in food deserts, teach people how to shop for healthy food or how to cook it so it's palatable, or in any way mitigate any of the socioeconomic factors that drive people to eating unhealthy food. In my experience, the average American is looking at restaurants like McDonalds, Dominoes/PizzaHut, a local burger joint, and a "fancy" place like Olive Garden. They wouldn't be able to get something healthy like lentil daal if they wanted to, with the closest equivalent being a McDonald's salad.