4 ms·
This is the sort of thing I'd love to see NIH have many parallel research tracks on this stuff, given backing & support to make the research happen & to release
by jauntywundrkind 2y ago
This is the sort of thing I'd love to see NIH have many parallel research tracks on this stuff, given backing & support to make the research happen & to release the work.
Precision medicine has so much potential, feels so in line for some really wild breakthroughs, with its ability to make so many exact & small operations.
I wonder where the Obama Precision Medicine (2015) work has gotten to so far. https://obamawhitehouse.archives.gov/the-press-office/2015/01/30/fact-sheet-president-obama-s-precision-medicine-initiative https://obamawhitehouse.archives.gov/the-press-office/2015/0...
- Onavo 2y agoBiden's son died of cancer so this is basically his pet project.
- melling 2y agoHe died from a glioblastoma. Car-t therapy is promising for that. https://www.massgeneral.org/news/press-release/clinical-trial-results-show-dramatic-regression-of-glioblastoma-after-next-generation-car-t-therapy https://www.massgeneral.org/news/press-release/clinical-tria...
- jjtheblunt 2y agohttps://www.bbc.com/news/world-australia-69006713 https://www.bbc.com/news/world-australia-69006713 Dr Scolyer is super interesting
- deleted 2y ago[deleted]
- biomcgary 2y agoThe biggest Obama spend was to create a research cohort (https://allofus.nih.gov/ https://allofus.nih.gov/). So far, it hasn't paid dividends in an appreciable way, but the UK Biobank (on which the US program is partially modeled) started in 2006 and is now contributing immensely to the development of medicine. The US program has the potential to be even more valuable if managed well, but I haven't seen overwhelming indications of reaching that potential yet; however, I think a few more years are needed for a clear evaluation.
- carbocation 2y agoSadly the All of Us program (of which I am a research subject [and researcher]) hasn't done any sort of imaging or ECG. They did draw blood, so that allowed for genome sequencing. That may also, in principle, allow for assaying new biomarkers (I don't believe anything like that has been funded though).
- westurner 2y ago2009-2010 Meaningful Use criteria required physicians to implement electronic care records. There's now FHIR for sharing records between different vendors' EHR systems. There's a JSONLD representation of FHIR. Which health and exercise apps can generate FHIR for self-reporting? Can participants forward their other EHR/EMR records to the All of Us program? Can participants or Red Cross or other blood donation services forward collected vitals and sample screening data to the All of Us program?
- carbocation 2y agoThe imaging reports are being imported, but not the images. The bigger issue is that clinical imaging is done due to medical indications. Medical indications dramatically confound the results. A key element of the UK Biobank's value is that imaging and ECG are being done without any clinical indication.
- westurner 2y agoSo they need more data from healthy patients when they're healthy in order to determine what's anomalous? SIEM tools do anomaly detection with lots of textual log data and sensor data. What would a Cost-effectiveness analysis say about collecting data from healthy patients: https://en.wikipedia.org/wiki/Cost-effectiveness_analysis https://en.wikipedia.org/wiki/Cost-effectiveness_analysis TIL the ROC curve applies to medical tests.
- biomcgary 2y agoThanks for the insight! I have used UKB data extensively, but haven't seen much from All of US, so I was wondering if I had missed something. . .
- aaronbrethorst 2y agoOstensibly this is part of the ‘cancer moonshot’ started during the Obama White House following the death of Beau Biden, as mentioned by another reply, and continued today by the Biden administration.