4 ms·

Because being fat is incredibly bad for you.

chiefalchemist 2y ago
My theory is the excess weight is more of a symptom than the root trigger. Eating too much makes the body work too hard. Frequent and excessive insulin swings, also unhealthy. Lack of movement, also undermines the systems' design. Etc. Etc. Prevent the body (and mind) from functioning naturally (in an historic / evolutionary sense) and bad tbings happen. Obesity is the cherry on top of the cake of unhealthy diet and lifestyle. The question is: what happens to Ozempic users over the long term? If you start on it at 18 y/o (or whatever the approved age is) what happens in 5 yrs, 10 yrs, etc. Statins eventually hit the wall so to speak, will these other system-altering drugs do the same?
ZeroGravitas 2y ago
Quote from comment by author, responding to a similar claim in the article comments: > That's not what this article says, and it's not true. Obesity isn't a risk factor for addiction, and is only a very weak risk factor for things like Parkinson's. Most of the people in these studies are probably diabetics taking it for diabetes and may not have even been obese to begin with.
toomuchtodo 2y ago
It patches a misconfigured reward system pathway in the brain using hormones. > There are two plausible places GLP-1 drugs could lower weight: the body or the brain. In the body, it could change stomach contraction rate, hormone production, etc. In the brain, it could control the mental sensation of hunger. To separate these two effects, scientists bred rats that only had GLP-1 receptors in the body vs. in the brain. The results were unequivocal: Ozempic and its relatives work in the brain. Although they have some effects in the body, these are short-lived and not really relevant to their mechanism of action for weight loss. This should've been obvious the moment there was evidence GLP-1 agonists were preventing addictive behaviors, versus solely digestive system effects. Interestingly, this works by crossing the blood brain barrier, so the next question is: can you speed up the effects by temporarily opening that barrier using ultrasound such is done for Alzheimer's treatment [1]? Also, what does an fMRI look like when someone is being treated with a GLP-1 [2]? [1] https://www.youtube.com/watch?v=7BGtVJ3lBdE https://www.youtube.com/watch?v=7BGtVJ3lBdE [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342891/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342891/

My theory is the excess weight is more of a symptom than the root trigger. Eating too much makes the body work too hard. Frequent and excessive insulin swings, also unhealthy. Lack of movement, also undermines the systems' design. Etc. Etc. Prevent the body (and mind) from functioning naturally (in an historic / evolutionary sense) and bad tbings happen. Obesity is the cherry on top of the cake of unhealthy diet and lifestyle. The question is: what happens to Ozempic users over the long term? If you start on it at 18 y/o (or whatever the approved age is) what happens in 5 yrs, 10 yrs, etc. Statins eventually hit the wall so to speak, will these other system-altering drugs do the same?

ZeroGravitas 2y ago

Quote from comment by author, responding to a similar claim in the article comments: > That's not what this article says, and it's not true. Obesity isn't a risk factor for addiction, and is only a very weak risk factor for things like Parkinson's. Most of the people in these studies are probably diabetics taking it for diabetes and may not have even been obese to begin with.

toomuchtodo 2y ago

It patches a misconfigured reward system pathway in the brain using hormones. > There are two plausible places GLP-1 drugs could lower weight: the body or the brain. In the body, it could change stomach contraction rate, hormone production, etc. In the brain, it could control the mental sensation of hunger. To separate these two effects, scientists bred rats that only had GLP-1 receptors in the body vs. in the brain. The results were unequivocal: Ozempic and its relatives work in the brain. Although they have some effects in the body, these are short-lived and not really relevant to their mechanism of action for weight loss. This should've been obvious the moment there was evidence GLP-1 agonists were preventing addictive behaviors, versus solely digestive system effects. Interestingly, this works by crossing the blood brain barrier, so the next question is: can you speed up the effects by temporarily opening that barrier using ultrasound such is done for Alzheimer's treatment [1]? Also, what does an fMRI look like when someone is being treated with a GLP-1 [2]? [1] https://www.youtube.com/watch?v=7BGtVJ3lBdE https://www.youtube.com/watch?v=7BGtVJ3lBdE [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342891/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342891/