I mean for AD it could perhaps be useful (of course it would not work for most other diseases) but legally that is very dicey because of informed consent. TBH w

I mean for AD it could perhaps be useful (of course it would not work for most other diseases) but legally that is very dicey because of informed consent. TBH we are not even sure if AD is one even one disease or if it multiple masquerading as one. We aren't even sure if amalyoid beta is a major contributor or cause. Or if it is an effect of the disease. The field is fraught with controversy and even seminal papers have been retracted. But getting back to that lack of understanding of the root cause this is why mice are useful, if we have a reproducible AD like phenotype in a transgenic mouse line that gives us some fundamental understanding of the underlying disease process in a way that likely wouldn't be possibly in a possibly polymorphic human disease population. You can also dose the mice at the same point in the disease process which is very useful in getting statistical significance for an effect. I also don't think you'd get enough people and they would be spread out all over the country. Hard to administer your proprietary drug in 100 different nursing homes. Much easier to walk down the mouse facility in the basement