2 ms·
Always first look at the raw data. Look at the scatter of the dots in raw expression plots (figure 1e dots). Maybe that's normal for this field, but adjacent
by markhahn 2y ago
Always first look at the raw data.
Look at the scatter of the dots in raw expression plots (figure 1e dots). Maybe that's normal for this field, but adjacent scores are all over the place, usually >50% different. That is: very noisy. Imagine the confidence intervals!
Maybe there's signal there, but to my eye, the basic acquisition technique is horrifyingly noisy.
This is only a short period and trivial N, but I also don't see anything systematic in the raw data related to sleep/wake phases.
- echelon 2y agoOnly three study participants, bucketing expression into 4-hour intervals, lots of fancy math to massage the data... I didn't like this paper.
- ineedaj0b 2y agoit's certainly a thing. everything has cycles. if it's most animals it'll be in humans. similar to how we knew animals could grow muscle from stretching, but we thought humans didn't. we now know we can grow muscle from stretching (it's not fun or easy) but it is a thing. needed a better study design. i think these results are from the last 2-3 years. this is a small study but was probably done for dirt cheap to prove it was somewhat workable. They can acquire better funding now to look for other cycles going on