5 ms·

Evidence for ~12-h ultradian gene programs in humans

67 points by XzetaU8 2y ago

Mistletoe 2y ago
Let me help everyone that doesn’t know the word like me. “Ultradian rhythms are biological cycles that repeat throughout a 24-hour day, with periods ranging from fractions of a second to several hours. They are different from circadian rhythms, which complete one cycle per day, and infradian rhythms, which have periods longer than a day.”
- markhahn 2y ago
  https://en.wikipedia.org/wiki/Ultradian_rhythm https://en.wikipedia.org/wiki/Ultradian_rhythm in short: cycles faster than a day. ultra- (more, greater), -dian (daily). analagous to circadian (cycle per day).
  - morsch 2y ago
    Approximately per day, more specifically. I never made that connection, interesting.
  - gnobbler 2y ago
    Ultra feels like an awkward way to phrase it. Faster (tachy?) might make more sense
    - kevin_thibedeau 2y ago
      That would mix Greek with Latin.
      - shermantanktop 2y ago
        I can’t hear you, the television is too loud. Now I’m going to get into my automobile that I bought with cryptocurrency and drive to Minneapolis.
      - gnobbler 2y ago
        in medicine, we start our frankenwords with 2 mixed languages and go up from there
        m463 2y ago
        Pharma goes to infinity (or is it zero?)
markhahn 2y ago
Always first look at the raw data. Look at the scatter of the dots in raw expression plots (figure 1e dots). Maybe that's normal for this field, but adjacent scores are all over the place, usually >50% different. That is: very noisy. Imagine the confidence intervals! Maybe there's signal there, but to my eye, the basic acquisition technique is horrifyingly noisy. This is only a short period and trivial N, but I also don't see anything systematic in the raw data related to sleep/wake phases.
- echelon 2y ago
  Only three study participants, bucketing expression into 4-hour intervals, lots of fancy math to massage the data... I didn't like this paper.
- ineedaj0b 2y ago
  it's certainly a thing. everything has cycles. if it's most animals it'll be in humans. similar to how we knew animals could grow muscle from stretching, but we thought humans didn't. we now know we can grow muscle from stretching (it's not fun or easy) but it is a thing. needed a better study design. i think these results are from the last 2-3 years. this is a small study but was probably done for dirt cheap to prove it was somewhat workable. They can acquire better funding now to look for other cycles going on

67 points by XzetaU8 2y ago

Let me help everyone that doesn’t know the word like me. “Ultradian rhythms are biological cycles that repeat throughout a 24-hour day, with periods ranging from fractions of a second to several hours. They are different from circadian rhythms, which complete one cycle per day, and infradian rhythms, which have periods longer than a day.”

markhahn 2y ago
https://en.wikipedia.org/wiki/Ultradian_rhythm https://en.wikipedia.org/wiki/Ultradian_rhythm in short: cycles faster than a day. ultra- (more, greater), -dian (daily). analagous to circadian (cycle per day).
- morsch 2y ago
  Approximately per day, more specifically. I never made that connection, interesting.
- gnobbler 2y ago
  Ultra feels like an awkward way to phrase it. Faster (tachy?) might make more sense
  - kevin_thibedeau 2y ago
    That would mix Greek with Latin.
    - shermantanktop 2y ago
      I can’t hear you, the television is too loud. Now I’m going to get into my automobile that I bought with cryptocurrency and drive to Minneapolis.
    - gnobbler 2y ago
      in medicine, we start our frankenwords with 2 mixed languages and go up from there
      - m463 2y ago
        Pharma goes to infinity (or is it zero?)

markhahn 2y ago

Always first look at the raw data. Look at the scatter of the dots in raw expression plots (figure 1e dots). Maybe that's normal for this field, but adjacent scores are all over the place, usually >50% different. That is: very noisy. Imagine the confidence intervals! Maybe there's signal there, but to my eye, the basic acquisition technique is horrifyingly noisy. This is only a short period and trivial N, but I also don't see anything systematic in the raw data related to sleep/wake phases.

echelon 2y ago
Only three study participants, bucketing expression into 4-hour intervals, lots of fancy math to massage the data... I didn't like this paper.
ineedaj0b 2y ago
it's certainly a thing. everything has cycles. if it's most animals it'll be in humans. similar to how we knew animals could grow muscle from stretching, but we thought humans didn't. we now know we can grow muscle from stretching (it's not fun or easy) but it is a thing. needed a better study design. i think these results are from the last 2-3 years. this is a small study but was probably done for dirt cheap to prove it was somewhat workable. They can acquire better funding now to look for other cycles going on