22 ms·

I appreciate you listing some of the complexities and issues of human trials. I learned some new information and perspectives that I have not considered before.

I appreciate you listing some of the complexities and issues of human trials. I learned some new information and perspectives that I have not considered before. However, I am not entirely convinced such trials could still not be efficiently and ethically conducted in some way. If I can have little "Organ Donor" checkbox on my license, then I do not see why I could not have a little "Alzheimer's Experiment Donor" checkbox either. I'm not saying it would be easy to conduct, and obviously there would have to be more stipulations than I have mentioned. Alzheimer's is an ultimately fatal disease and ain't a pretty way to go out. What do these sufferers have to lose? You can't kill a deadman.

AbstractH24 2y ago
Rationally what you are saying makes sense, but the problem with progressive diseases like Alzheimer’s is not just defining the point at which quality of life is so poor you might as well throw spaghetti at the wall with the hope of helping society if not the individual, but also getting people and their caretakers to admit they’ve reached that point. Then there is potential legal liability if someone disputes a doctor’s choice after the fact.
jdoe2020 2y ago
I mean for AD it could perhaps be useful (of course it would not work for most other diseases) but legally that is very dicey because of informed consent. TBH we are not even sure if AD is one even one disease or if it multiple masquerading as one. We aren't even sure if amalyoid beta is a major contributor or cause. Or if it is an effect of the disease. The field is fraught with controversy and even seminal papers have been retracted. But getting back to that lack of understanding of the root cause this is why mice are useful, if we have a reproducible AD like phenotype in a transgenic mouse line that gives us some fundamental understanding of the underlying disease process in a way that likely wouldn't be possibly in a possibly polymorphic human disease population. You can also dose the mice at the same point in the disease process which is very useful in getting statistical significance for an effect. I also don't think you'd get enough people and they would be spread out all over the country. Hard to administer your proprietary drug in 100 different nursing homes. Much easier to walk down the mouse facility in the basement

AbstractH24 2y ago

Rationally what you are saying makes sense, but the problem with progressive diseases like Alzheimer’s is not just defining the point at which quality of life is so poor you might as well throw spaghetti at the wall with the hope of helping society if not the individual, but also getting people and their caretakers to admit they’ve reached that point. Then there is potential legal liability if someone disputes a doctor’s choice after the fact.

jdoe2020 2y ago

I mean for AD it could perhaps be useful (of course it would not work for most other diseases) but legally that is very dicey because of informed consent. TBH we are not even sure if AD is one even one disease or if it multiple masquerading as one. We aren't even sure if amalyoid beta is a major contributor or cause. Or if it is an effect of the disease. The field is fraught with controversy and even seminal papers have been retracted. But getting back to that lack of understanding of the root cause this is why mice are useful, if we have a reproducible AD like phenotype in a transgenic mouse line that gives us some fundamental understanding of the underlying disease process in a way that likely wouldn't be possibly in a possibly polymorphic human disease population. You can also dose the mice at the same point in the disease process which is very useful in getting statistical significance for an effect. I also don't think you'd get enough people and they would be spread out all over the country. Hard to administer your proprietary drug in 100 different nursing homes. Much easier to walk down the mouse facility in the basement