3 ms·

I mean, I don't think many people with Alzheimers are having kids. And while mice are genetically similar to us the 'Alzheimers' they're made to have isn't the

I mean, I don't think many people with Alzheimers are having kids. And while mice are genetically similar to us the 'Alzheimers' they're made to have isn't the same disease so we might have been chasing our tail for the last few decades.

jdoe2020 2y ago
Yes but many people that have had kids get Alzheimer's. AD isnt aggressively selected against because it is only deleterious past reproductive age. It's true but AD is likely not one disease but is many different mutations causing a family of shared symptoms which makes it hard to study. It's often better to gain a mechanistic understanding in a reductive model because you'd not have the statistical power in a mixed population to see anything at all.