3 ms·

And what of these mouse studies?

by arijun 2y ago

BoredPositron 2y ago
Mice are excellent models for human disease due to their genetic similarity, with 98% of human genes having mouse counterparts. Their comparable reproductive and nervous systems, along with susceptibility to similar diseases, make them valuable research subjects. DNA manipulation in mice, through breeding or gene editing techniques like CRISPR-Cas, allows researchers to study specific genes and diseases. Using mice is faster than conducting initial studies on humans, allowing for rapid testing of hypotheses and treatments before moving to human trials. Mice also have much shorter lifespans and faster reproductive cycles, enabling researchers to study diseases and genetic effects across multiple generations in a fraction of the time required for human studies. Maybe if OP would like to sacrifice their children and grand children... sounds a bit insane doesn't it? Here is a nice paper for you to read https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/
- jdoe2020 2y ago
  Also you can cut them open when you are done. Can't do that to people. Sometimes you need biochemical tests and imaging very quickly post mortem to avoid changes in protein postranslational modifications. This is particularly important in AD studies. We needed to kill the mice and have their hippocampi in a grinder with phosphatase inhitor in under 10 minutes.
- robwwilliams 2y ago
  True enough—but get the genetic diversity incorporated into rodent models—not just fully inbred C57BL/6J and Fischer 344. And if the experimental design calls for replicable genometypes (cases and controls) then just use sets of diverse types of F1 hybrids.
- Auracle 2y ago
  I mean, I don't think many people with Alzheimers are having kids. And while mice are genetically similar to us the 'Alzheimers' they're made to have isn't the same disease so we might have been chasing our tail for the last few decades.
  - jdoe2020 2y ago
    Yes but many people that have had kids get Alzheimer's. AD isnt aggressively selected against because it is only deleterious past reproductive age. It's true but AD is likely not one disease but is many different mutations causing a family of shared symptoms which makes it hard to study. It's often better to gain a mechanistic understanding in a reductive model because you'd not have the statistical power in a mixed population to see anything at all.

And what of these mouse studies?

by arijun 2y ago

And what of these mouse studies?

Mice are excellent models for human disease due to their genetic similarity, with 98% of human genes having mouse counterparts. Their comparable reproductive and nervous systems, along with susceptibility to similar diseases, make them valuable research subjects. DNA manipulation in mice, through breeding or gene editing techniques like CRISPR-Cas, allows researchers to study specific genes and diseases. Using mice is faster than conducting initial studies on humans, allowing for rapid testing of hypotheses and treatments before moving to human trials. Mice also have much shorter lifespans and faster reproductive cycles, enabling researchers to study diseases and genetic effects across multiple generations in a fraction of the time required for human studies. Maybe if OP would like to sacrifice their children and grand children... sounds a bit insane doesn't it? Here is a nice paper for you to read https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/

jdoe2020 2y ago
Also you can cut them open when you are done. Can't do that to people. Sometimes you need biochemical tests and imaging very quickly post mortem to avoid changes in protein postranslational modifications. This is particularly important in AD studies. We needed to kill the mice and have their hippocampi in a grinder with phosphatase inhitor in under 10 minutes.
robwwilliams 2y ago
True enough—but get the genetic diversity incorporated into rodent models—not just fully inbred C57BL/6J and Fischer 344. And if the experimental design calls for replicable genometypes (cases and controls) then just use sets of diverse types of F1 hybrids.
Auracle 2y ago
I mean, I don't think many people with Alzheimers are having kids. And while mice are genetically similar to us the 'Alzheimers' they're made to have isn't the same disease so we might have been chasing our tail for the last few decades.
- jdoe2020 2y ago
  Yes but many people that have had kids get Alzheimer's. AD isnt aggressively selected against because it is only deleterious past reproductive age. It's true but AD is likely not one disease but is many different mutations causing a family of shared symptoms which makes it hard to study. It's often better to gain a mechanistic understanding in a reductive model because you'd not have the statistical power in a mixed population to see anything at all.