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"Wei et al., have studied the subunit composition of γ-aminobutyric acid type A receptors responsible for the tonic inhibition of parvalbumin positive interneur
by Beijinger 2y ago
"Wei et al., have studied the subunit composition of γ-aminobutyric acid type A receptors responsible for the tonic inhibition of parvalbumin positive interneurons and identified a small molecule (DDL-920) as a potent, efficacious, and selective negative allosteric modulator of these receptors."
A SMALL molecule? And not formula? Odd.
- dillydogg 2y agoI the term small molecule has a specific meaning in biopharma and the biochemical formula is almost certainly not going to reveal much information. Might as well just use the convention of the compound ID. Related, in the supplemental data the compound's reference is Ref XX. Must have slipped by the reviewers.
- robwwilliams 2y agoThat error is on the PNAS editorial team - not on the reviewers.
- aftbit 2y agoI'm not entirely sure I understand your comment, but "small molecule" is a drug discovery term of art, and includes things with relatively high molecular weights and complex formulae. Anything sub-1000 daltons is generally considered a "small molecule". https://en.wikipedia.org/wiki/Small_molecule https://en.wikipedia.org/wiki/Small_molecule
- Beijinger 2y agoWith a PhD in Chemistry, I understand what a "small molecule" is. But by looking at the link for a few seconds, I found no further information about the compound. I am not a big fan of "secret sauce". Maybe I missed it in the paper.
- jdoe2020 2y agoYeah I was looking for that but didn't find it in the paper, someone else here linked to pubchem in this thread. It's 3-(4-pyridinyl)-2-(napthylmethyl)-pyrazole N-oxide or something like that. My IUPAC is a bit rusty