Without mention of the number of study participants or risk, I was a bit suspicious, but it's not a tiny sample size, and not a low-risk group. From the paper:

Without mention of the number of study participants or risk, I was a bit suspicious, but it's not a tiny sample size, and not a low-risk group. From the paper: > Among 5338 participants who were initially HIV-negative, 55 incident HIV infections were observed: 0 infections among 2134 participants in the lenacapavir group The infections in the control groups were in people taking other preventative medication, not nothing.