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You don't necesarily need gene therapy to "turn off" genes. You can just (temporarily) silence genes. Here's a podcast episode about just that (with the example

You don't necesarily need gene therapy to "turn off" genes. You can just (temporarily) silence genes. Here's a podcast episode about just that (with the example of prion disease immunity): https://traffic.libsyn.com/secure/twiv/TWiV1127.mp3?dest-id=25528 https://traffic.libsyn.com/secure/twiv/TWiV1127.mp3?dest-id=... Also a fun related fact that I remember from Kurtzgesagt: whales should get tons of cancer (for being so huge), but they (almost?) never do. I'm convinced that there are feasible ways.

amanaplanacanal 2y ago
They figure out how to prevent cancer, but it makes you huge and your limbs turn into flippers.
- mystified5016 2y ago
  A cure for cancer and a return to the oceans? My friend, this is a feature not a bug.
Kalanos 2y ago
all drugs "temporarily silence genes" by acting on the gene's target protein until the dose degrades. silencing typically refers to siRNA/RNAi. There are only 7 siRNA approved, all for liver diseases