5 ms·

Surprised there is no mention of Bryan Johnson. Whatever you think of his methods, he has certainly done a lot to popularize longevity research in the last coup

Surprised there is no mention of Bryan Johnson. Whatever you think of his methods, he has certainly done a lot to popularize longevity research in the last couple years. Also no mention of rapamycin and related research on immune modulating pathways.

abhishaike 2y ago
sure but he hasn’t contributed much to the actual research itself, i agree that he’s done cultural contributions, but afaict he isn’t funding much rapamycin is something i left out yeah, just was something i was less interested in + believe in less. i really only covered sirtuins because its had such a large cultural impact through David Sinclair’s book on aging
- Teever 2y ago
  What drives your skepticism of rapamycin for anti-aging?
- criddell 2y ago
  > he hasn't contributed much to the actual research itself From what I've read, he's done quite a bit of this but it's been restricted to a population of one. If his healthspan hits 120, the experiment he's run has been successful, no? He's already 46 so we will have a result relatively soon (within 60-70 years).
  - indoordin0saur 2y ago
    In 20 or 30 years you can look and see if he's 99th percentile for his age along whatever metrics (mile run time, VO2 max, skin elasticity, etc.) and that will be an obvious sign of a successful experiment.
  - Temporary_31337 2y ago
    Statistically it will not be a very useful scientific experiment - too many variables, too small sample size. Plus he will die a lot sooner from all the pills he is taking.
    - criddell 2y ago
      IMHO, even experiments that don't seem useful today can still be interesting. Dying at age 48, 80, or 150 are all potentially interesting results.
    - ericmcer 2y ago
      I really doubt he will die young, people who die in their 40s usually have something they don't notice until it is too late (heart disease, cancer). There is no way he would not notice something like that lol. The amount of testing he undergoes is as interesting as the regimen itself to me. So many things that take you out are very survivable if caught in advance, and he is going to catch everything.
  - ben_w 2y ago
    Results on those timescales are a bit too much of a Pascal's Wager for my liking.
    - criddell 2y ago
      How do you get longevity results on short timescales?
      - ben_w 2y ago
        GM lab rats if you want in-vivo, better computational models of you want in-silico. Both are happening; I have no idea what ultimate (or indeed present) limits each has.
        criddell 2y ago
        Rat experiments would give you longevity results for rats which may or may not be the same in humans. AFAIK, the only way to get actual results for humans is to run the experiment.
infecto 2y ago
After seeing some of his daily routines I am not so sure he is that interesting to talk about. Lots of pseudoscience devices, I imagine his caloric restriction has been the biggest impact.
- hobofan 2y ago
  Yeah, a lot of his approach also seems to be to try everything that could remotely have the possibility of working, and if it works it works, if it doesn't he can afford the expensive pee and the time wasted. For most everyone else that has to budget (both money and time) and try to figure out what core supplements and practices could be beneficial, that doesn't really help.
- ericmcer 2y ago
  Caloric restriction thing is true, but is also what he advocates. He always says if you are not sleeping well or eating right don't worry about anything else. Red light therapy, supplements, stem cells and all the other expensive experiments he does are all less effective and shouldn't even be considered until your sleep, exercise and diet are good. I am not jumping into his program, but I am definitely keeping an eye on him. If he is still doing the same protocol and he looks the same 10 years from now it will get difficult to keep criticizing it.
Gettingolderev 2y ago
[dead]
Flatcircle 2y ago
lol, bro takes 100 pills a day. With all the tainted supplements in the world, he’s just playing Russian roulette with pills.

abhishaike 2y ago

sure but he hasn’t contributed much to the actual research itself, i agree that he’s done cultural contributions, but afaict he isn’t funding much rapamycin is something i left out yeah, just was something i was less interested in + believe in less. i really only covered sirtuins because its had such a large cultural impact through David Sinclair’s book on aging

Teever 2y ago
What drives your skepticism of rapamycin for anti-aging?
criddell 2y ago
> he hasn't contributed much to the actual research itself From what I've read, he's done quite a bit of this but it's been restricted to a population of one. If his healthspan hits 120, the experiment he's run has been successful, no? He's already 46 so we will have a result relatively soon (within 60-70 years).
- indoordin0saur 2y ago
  In 20 or 30 years you can look and see if he's 99th percentile for his age along whatever metrics (mile run time, VO2 max, skin elasticity, etc.) and that will be an obvious sign of a successful experiment.
- Temporary_31337 2y ago
  Statistically it will not be a very useful scientific experiment - too many variables, too small sample size. Plus he will die a lot sooner from all the pills he is taking.
  - criddell 2y ago
    IMHO, even experiments that don't seem useful today can still be interesting. Dying at age 48, 80, or 150 are all potentially interesting results.
  - ericmcer 2y ago
    I really doubt he will die young, people who die in their 40s usually have something they don't notice until it is too late (heart disease, cancer). There is no way he would not notice something like that lol. The amount of testing he undergoes is as interesting as the regimen itself to me. So many things that take you out are very survivable if caught in advance, and he is going to catch everything.
- ben_w 2y ago
  Results on those timescales are a bit too much of a Pascal's Wager for my liking.
  - criddell 2y ago
    How do you get longevity results on short timescales?
    - ben_w 2y ago
      GM lab rats if you want in-vivo, better computational models of you want in-silico. Both are happening; I have no idea what ultimate (or indeed present) limits each has.
      - criddell 2y ago
        Rat experiments would give you longevity results for rats which may or may not be the same in humans. AFAIK, the only way to get actual results for humans is to run the experiment.

infecto 2y ago

After seeing some of his daily routines I am not so sure he is that interesting to talk about. Lots of pseudoscience devices, I imagine his caloric restriction has been the biggest impact.

hobofan 2y ago
Yeah, a lot of his approach also seems to be to try everything that could remotely have the possibility of working, and if it works it works, if it doesn't he can afford the expensive pee and the time wasted. For most everyone else that has to budget (both money and time) and try to figure out what core supplements and practices could be beneficial, that doesn't really help.
ericmcer 2y ago
Caloric restriction thing is true, but is also what he advocates. He always says if you are not sleeping well or eating right don't worry about anything else. Red light therapy, supplements, stem cells and all the other expensive experiments he does are all less effective and shouldn't even be considered until your sleep, exercise and diet are good. I am not jumping into his program, but I am definitely keeping an eye on him. If he is still doing the same protocol and he looks the same 10 years from now it will get difficult to keep criticizing it.

Gettingolderev 2y ago

[dead]

Flatcircle 2y ago

lol, bro takes 100 pills a day. With all the tainted supplements in the world, he’s just playing Russian roulette with pills.