3 ms·
Ah thanks. This is a set of comments I get. Appreciated. The headlines that read “Discovery of Gene X for Autism, Intelligence, Prostate Cancer, even Religiosi
by robwwilliams 2y ago
Ah thanks. This is a set of comments I get. Appreciated.
The headlines that read “Discovery of Gene X for Autism, Intelligence, Prostate Cancer, even Religiosity”
are definitely crude and wrong click-bait.
Regarding heritability: Almost all of us in genetics use heritability as an operation measure of how difficult it will be to uncover the often large set of DNA variants that modulate trait variation. Since I am now trying my best to map DNA variants that modulate lifespan I need to know how hard I am going to need to work and what same size I will need.
See this recent paper:
https://pubmed.ncbi.nlm.nih.gov/36173858/ https://pubmed.ncbi.nlm.nih.gov/36173858/
Turns out we will need about 25000 mice to do a good job. And our result will depend strongly on the quirky environment in which we raise our mice; almost equally quirky as human environments, but not as noisy and plagued by as much disease and warfare!
Almost all of us in the field of quantitative genetics know that heritability is strongly dependent on environmental context. There is no heritability for nicotine addiction in a world with no nicotine. This message gets lost in translation—why we seem to recursively fight pointless nature-nurture battles.