5 ms·

Immunotherapy works. I run a company (YC w21) that wants to eliminate allergies forever. It's ancient medicine to manage symptoms with antihistamines when we ca

Immunotherapy works. I run a company (YC w21) that wants to eliminate allergies forever. It's ancient medicine to manage symptoms with antihistamines when we can remove the root cause completely. Right now, we fix cat, dog, pet, pollen, and dust allergies. In a few years, we'll be doing nuts. Our launch HN: https://news.ycombinator.com/item?id=26227807 https://news.ycombinator.com/item?id=26227807 company: https://www.wyndly.com/ https://www.wyndly.com/ book a visit with a doc: https://www.wyndly.com/products/allergy-doctor-consult-online https://www.wyndly.com/products/allergy-doctor-consult-onlin... Or just start with an allergy test: https://www.wyndly.com/products/at-home-allergy-test https://www.wyndly.com/products/at-home-allergy-test US Only right now. If you can help us expand into your country, contact me at aakash@wyndly.com

helloworld42024 2y ago
This is a brilliant idea. The product and system also look extremely well put together.
snowpid 2y ago
Can you show us any peer reviewed paper ?
- KennyBlanken 2y ago
  I tried searching pubmed but turns out there are a lot of Mana Shahs working in bio research and pharma. The big question for me is whether this is a permanent fix or if you have to keep taking their tablets (at $99-ish a month, it looks like?) Unfortunately this doesn't look to be covered by my insurance as the at-home test is not administered by a doctor.
  - snowpid 2y ago
    My insurance in Germany only accepts peer reviewed stuff anyway so I keep waiting.
  - munchbunny 2y ago
    My toddler is on oral immunotherapy for peanuts, and unless he outgrows it or chooses to stop treatment, or new research comes out, he is going to be doing oral immunotherapy for life. Fortunately, peanuts aren’t expensive. The expensive part is the trained allergist whose job is to keep up with the research, and in my case, who I suspect will be publishing interesting papers in the next few years.
KennyBlanken 2y ago
How is this different or better compared to diagnostics and treatments available from allergists? At least one office in my area says they do immunotherapy and desensitization.
azinman2 2y ago
I have some allergies that the allergy doc’s test doesn’t show; he said they are there but not by histamine reaction. Do you support these? Also, what about things like gluten and dairy sensitivity?
- Atotalnoob 2y ago
  Most people with a gluten allergy have celiacs which is not an allergy at all, but rather an autoimmune disorder. It’s similar enough to an allergy, though
  - tczMUFlmoNk 2y ago
    A wheat allergy, though, is fairly common: order of 1% per [1], similar to celiac. And if you're allergic to wheat, then it's suffices to avoid gluten, since wheat contains gluten. (Also, there are forms of gluten intolerance that are neither a wheat allergy nor celiac.) [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097276/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097276/
  - azinman2 2y ago
    But for those of us who have non-celiac gluten sensitivity, does this help?
superfrank 2y ago
I've done two rounds of sublingual drops over the past 8 years and both times I've seen no noticeable improvement. Once was directly through my doctor and the second time was through a service similar to this (Curex). I don't doubt this works for some people, but I also don't think it works for everyone. I had much better results with shots.

helloworld42024 2y ago

This is a brilliant idea. The product and system also look extremely well put together.

snowpid 2y ago

Can you show us any peer reviewed paper ?

KennyBlanken 2y ago
I tried searching pubmed but turns out there are a lot of Mana Shahs working in bio research and pharma. The big question for me is whether this is a permanent fix or if you have to keep taking their tablets (at $99-ish a month, it looks like?) Unfortunately this doesn't look to be covered by my insurance as the at-home test is not administered by a doctor.
- snowpid 2y ago
  My insurance in Germany only accepts peer reviewed stuff anyway so I keep waiting.
- munchbunny 2y ago
  My toddler is on oral immunotherapy for peanuts, and unless he outgrows it or chooses to stop treatment, or new research comes out, he is going to be doing oral immunotherapy for life. Fortunately, peanuts aren’t expensive. The expensive part is the trained allergist whose job is to keep up with the research, and in my case, who I suspect will be publishing interesting papers in the next few years.

KennyBlanken 2y ago

How is this different or better compared to diagnostics and treatments available from allergists? At least one office in my area says they do immunotherapy and desensitization.

azinman2 2y ago

I have some allergies that the allergy doc’s test doesn’t show; he said they are there but not by histamine reaction. Do you support these? Also, what about things like gluten and dairy sensitivity?

Atotalnoob 2y ago
Most people with a gluten allergy have celiacs which is not an allergy at all, but rather an autoimmune disorder. It’s similar enough to an allergy, though
- tczMUFlmoNk 2y ago
  A wheat allergy, though, is fairly common: order of 1% per [1], similar to celiac. And if you're allergic to wheat, then it's suffices to avoid gluten, since wheat contains gluten. (Also, there are forms of gluten intolerance that are neither a wheat allergy nor celiac.) [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097276/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097276/
- azinman2 2y ago
  But for those of us who have non-celiac gluten sensitivity, does this help?

superfrank 2y ago

I've done two rounds of sublingual drops over the past 8 years and both times I've seen no noticeable improvement. Once was directly through my doctor and the second time was through a service similar to this (Curex). I don't doubt this works for some people, but I also don't think it works for everyone. I had much better results with shots.