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MinuteEarth - Dogs vs Cats: The Diversity Paradox https://youtu.be/g1gj5yn5IyU https://youtu.be/g1gj5yn5IyU The 14 genes mentioned that control dog size: https
by shagie 2y ago
MinuteEarth - Dogs vs Cats: The Diversity Paradox https://youtu.be/g1gj5yn5IyU https://youtu.be/g1gj5yn5IyU
The 14 genes mentioned that control dog size: https://research.nhgri.nih.gov/dog_genome/study_descriptions/study-body_size.shtml https://research.nhgri.nih.gov/dog_genome/study_descriptions...
The concept behind this is https://en.wikipedia.org/wiki/Phenotypic_plasticity https://en.wikipedia.org/wiki/Phenotypic_plasticity
And linking to a reddit post about this from a while back - https://www.reddit.com/r/askscience/comments/1hhzcn/why_do_we_have_different_sized_dogs_but_all_the/ https://www.reddit.com/r/askscience/comments/1hhzcn/why_do_w...
Elevated basal slippage mutation rates among the Canidae - https://pubmed.ncbi.nlm.nih.gov/17437958/ https://pubmed.ncbi.nlm.nih.gov/17437958/
> The remarkable responsiveness of dog morphology to selection is a testament to the mutability of mammals. The genetic sources of this morphological variation are largely unknown, but some portion is due to tandem repeat length variation in genes involved in development. Previous analysis of tandem repeats in coding regions of developmental genes revealed fewer interruptions in repeat sequences in dogs than in the orthologous repeats in humans, as well as higher levels of polymorphism, but the fragmentary nature of the available dog genome sequence thwarted attempts to distinguish between locus-specific and genome-wide origins of this disparity. Using whole-genome analyses of the human and recently completed dog genomes, we show that dogs possess a genome-wide increase in the basal germ-line slippage mutation rate. Building on the approach that gave rise to the initial observation in dogs, we sequenced 55 coding repeat regions in 42 species representing 10 major carnivore clades and found that a genome-wide elevated slippage mutation rate is a derived character shared by diverse wild canids, distinguishing them from other Carnivora. A similarly heightened slippage profile was also detected in rodents, another taxon exhibiting high diversity and rapid evolvability. The correlation of enhanced slippage rates with major evolutionary radiations suggests that the possession of a "slippery" genome may bestow on some taxa greater potential for rapid evolutionary change.
(and if you're interested in genetic diversity and fossil records, https://en.wikipedia.org/wiki/Cat_gap https://en.wikipedia.org/wiki/Cat_gap )