That is painting with too broad a brush. Some animal studies do tightly mimic human responses (eg CV in dogs). Others significantly less so. For something as fo

That is painting with too broad a brush. Some animal studies do tightly mimic human responses (eg CV in dogs). Others significantly less so. For something as foundational as energy balance, I would expect it to be better than other biological pathways. Should we all start mainlining the compound today? No, but this is a data point which can be followed with more study. Biology is super complex with many non intuitive relationships you can only discover through experimentation. If we can only rely on human trials, expect the pace of biological research to come to a crawl. Nobody likes relying upon animals, but it is that or we give up on ethics and start experimenting on orphans.