If you like shrinkage (I do), I highly recommend the work of Matthew Stephens, e.g. ashr [1] and vash [2] for shrinkage based on an empirically derived prior.

If you like shrinkage (I do), I highly recommend the work of Matthew Stephens, e.g. ashr [1] and vash [2] for shrinkage based on an empirically derived prior. [1] https://cran.r-project.org/web/packages/ashr/index.html https://cran.r-project.org/web/packages/ashr/index.html [2] https://github.com/mengyin/vashr https://github.com/mengyin/vashr