Indeed, we know so little about the nature of things that it's really a bit premature to hold our current understanding as the final word over what will happen.

Indeed, we know so little about the nature of things that it's really a bit premature to hold our current understanding as the final word over what will happen. For one thing, a large fraction of possibilities involves simulations. In a simulation with successful traits, some constants and elementary particles might turn out to have been misunderstood later on...