My knowledge of endocrinology is pretty weak, but I feel like given what we know about human variation in general (and, perhaps, the very existence of type 2 di

My knowledge of endocrinology is pretty weak, but I feel like given what we know about human variation in general (and, perhaps, the very existence of type 2 diabetes in people with healthy lifestyles), it should pretty much be the null hypothesis that some fraction of the population has a generally lower/deficient baseline of GLP-1 function and might therefore see a broad range of benefits from GLP-1 agonists, in the same way that conditions like hypogonadism, hypothyroidism, Addison's disease, etc. are a thing. I also wouldn't be surprised if we find out that there's an opposite end of the spectrum associated with anorexia/orthorexia. I don't have a citation, but I've seen mentions that there are already anecdotal reports of people discontinuing GLP-1 agonists because they were emotionally disturbed by the fact that it made them "hate" food.