3 ms·

I keep seeing studies about positive outcomes from Ozempic, it truly appears to be a miracle drug. For example this: https://x.com/ScienceMagazine/status/18163

by mrtksn 2y ago

I keep seeing studies about positive outcomes from Ozempic, it truly appears to be a miracle drug. For example this: https://x.com/ScienceMagazine/status/1816398064011083922 https://x.com/ScienceMagazine/status/1816398064011083922 It even appears to help with psychiatric disorders and neurodegenerative diseases. BTW, the the drug is much cheaper in EU. Maybe because it's an EU drug? I don't know but in Greece it's about 100 EUR and in Bulgaria even cheaper at 90EUR.

nwienert 2y ago
Fixes immune system issues too, I can say firsthand it's a near miracle for mine, and I wasn't overweight or out of shape when I went on.
- voisin 2y ago
  What type of immune issues does it fix? Please elaborate.
  - consteval 2y ago
    Obesity raising your risk of just about every autoimmune disease. Also symptoms are often lowered when you're thinner, for those who have already developed the disease.
    - nwienert 2y ago
      No it's separate from the obesity effects. For me I have both Familial Mediterranean Fever and hypermobile Ehlers Danlos, I get consistent effects from them (~monthly basis) but since Tirzepatide have had none now nearly 2 years. I can actually feel the lack of fasciculation and other effects quite strongly on vs off (I've cycled off a few times). There's already some research into Parksons[0] and we know it has effects lowering TNF-a, IL-6 and other inflammatory protein signals [1]. [0] https://www.sciencedirect.com/science/article/pii/S1568163723001381 https://www.sciencedirect.com/science/article/pii/S156816372... [1] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1146960/full https://www.frontiersin.org/journals/pharmacology/articles/1...
paulpauper 2y ago
I feel like we're on the cusp of something much bigger. This class of drugs will in the long term reduce healthcare spending.
silverquiet 2y ago
There are drugs that can counteract some of the negative effects of obesity, but none of them will bring your lab values in line anywhere near as much as losing the weight. I suspect that not being obese is essentially the miracle drug; Ozempic obviously helps people to lose weight.
0xcde4c3db 2y ago
My knowledge of endocrinology is pretty weak, but I feel like given what we know about human variation in general (and, perhaps, the very existence of type 2 diabetes in people with healthy lifestyles), it should pretty much be the null hypothesis that some fraction of the population has a generally lower/deficient baseline of GLP-1 function and might therefore see a broad range of benefits from GLP-1 agonists, in the same way that conditions like hypogonadism, hypothyroidism, Addison's disease, etc. are a thing. I also wouldn't be surprised if we find out that there's an opposite end of the spectrum associated with anorexia/orthorexia. I don't have a citation, but I've seen mentions that there are already anecdotal reports of people discontinuing GLP-1 agonists because they were emotionally disturbed by the fact that it made them "hate" food.

by mrtksn 2y ago

nwienert 2y ago

Fixes immune system issues too, I can say firsthand it's a near miracle for mine, and I wasn't overweight or out of shape when I went on.

voisin 2y ago
What type of immune issues does it fix? Please elaborate.
- consteval 2y ago
  Obesity raising your risk of just about every autoimmune disease. Also symptoms are often lowered when you're thinner, for those who have already developed the disease.
  - nwienert 2y ago
    No it's separate from the obesity effects. For me I have both Familial Mediterranean Fever and hypermobile Ehlers Danlos, I get consistent effects from them (~monthly basis) but since Tirzepatide have had none now nearly 2 years. I can actually feel the lack of fasciculation and other effects quite strongly on vs off (I've cycled off a few times). There's already some research into Parksons[0] and we know it has effects lowering TNF-a, IL-6 and other inflammatory protein signals [1]. [0] https://www.sciencedirect.com/science/article/pii/S1568163723001381 https://www.sciencedirect.com/science/article/pii/S156816372... [1] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1146960/full https://www.frontiersin.org/journals/pharmacology/articles/1...

paulpauper 2y ago

I feel like we're on the cusp of something much bigger. This class of drugs will in the long term reduce healthcare spending.

silverquiet 2y ago

There are drugs that can counteract some of the negative effects of obesity, but none of them will bring your lab values in line anywhere near as much as losing the weight. I suspect that not being obese is essentially the miracle drug; Ozempic obviously helps people to lose weight.

0xcde4c3db 2y ago

My knowledge of endocrinology is pretty weak, but I feel like given what we know about human variation in general (and, perhaps, the very existence of type 2 diabetes in people with healthy lifestyles), it should pretty much be the null hypothesis that some fraction of the population has a generally lower/deficient baseline of GLP-1 function and might therefore see a broad range of benefits from GLP-1 agonists, in the same way that conditions like hypogonadism, hypothyroidism, Addison's disease, etc. are a thing. I also wouldn't be surprised if we find out that there's an opposite end of the spectrum associated with anorexia/orthorexia. I don't have a citation, but I've seen mentions that there are already anecdotal reports of people discontinuing GLP-1 agonists because they were emotionally disturbed by the fact that it made them "hate" food.