4 ms·
I don’t think the “in mice” torpedo is as effective in this case. As long as the human tau protein they are modified to express is the same protein targeted in
by throwthrowuknow 2y ago
I don’t think the “in mice” torpedo is as effective in this case. As long as the human tau protein they are modified to express is the same protein targeted in humans then the action of this antibody should be equivalent. We’re talking about extracellular processes here so it should be very similar to how it would work in any animal. ie we don’t have to worry as much about the other differences normally present inside cells of genetically modified mice. Yes there could be confounding variables present in the space between the cells but if this interaction works both in vitro and in vivo it should be generally the same anywhere. All that’s left is safety which should be determinable in the usual ways eg more animal trials.
- 1970-01-01 2y ago>As long as the human tau protein they are modified to express is the same protein targeted in humans I would be surprised if any of this was true. Protein does not behave this way: https://www.uniprot.org/uniprotkb?query=Tau https://www.uniprot.org/uniprotkb?query=Tau
- drekk 2y agoYou linked a database of Tau proteins naturally expressed by different species of animals. The mice in this study are a breed of mutants that express the human version of the Tau protein.
- ta988 2y agoUnfortunately those mice are really not a great model. They express the human tau yes, but that expression is sensitive to a lot of factors which makes human-inactive treatment work well on them.