Yes, just ensure you can keep them cool. I have an old m40 that opened up my options with 24GB of VRAM, installed on a traditional case with a 3d printed cooler

Yes, just ensure you can keep them cool. I have an old m40 that opened up my options with 24GB of VRAM, installed on a traditional case with a 3d printed cooler adapter + fan. While it isn't always fun getting older cards to work, it is certainly viable (and scalable if needed).