There's a reason I'd linked the NYC "pestilence" chart. The first broad-spectrum antibiotic, penicillin, wasn't discovered until 1928, wasn't administered medi

There's a reason I'd linked the NYC "pestilence" chart. The first broad-spectrum antibiotic, penicillin, wasn't discovered until 1928, wasn't administered medically until 1930, and then still experimentally, and wasn't mass produced until near or after the end of WWII, with 2.3 million doses available the invasion of Normandy (Spring 1944) and nearly 650 billion units by June 1945). General availability to the US public didn't occur until 15 March 1945. Yet if we look at the NYC mortality graph, mortality falls tremendously during the latter part of the 19th century and attains the level it sustained through most of the 20th century by 1920, well before penicillin was even first isolated, let alone applied broadly. If you compare against the date of penicillin general availability, mortality actually rises until about 1970, after which there is a plateau, followed by a comparatively sharp decline (though minor in context with the 1850--1920 decrease) after 1990. Antibiotics are invisible on that chart.