My understand was the side effects were mostly stomach related, and that in turn is related to a specific gene. In theory people without the gene were far more

My understand was the side effects were mostly stomach related, and that in turn is related to a specific gene. In theory people without the gene were far more likely to tolerate ibuprofen. Excessive alcohol use is also an issue. https://pubmed.ncbi.nlm.nih.gov/27092633/ https://pubmed.ncbi.nlm.nih.gov/27092633/