Not in mice AFAIK, but they've done it with flies which have an even better generational turnaround time (although are less alike to us). Selective breeding of

Not in mice AFAIK, but they've done it with flies which have an even better generational turnaround time (although are less alike to us). Selective breeding of fruit flies at their oldest possible age for breeding, yields longer lifespans in as few as ~12 generations. And the inverse, yields shorter lifespans.