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The translation rate is surprisingly bad. > Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regula
by hombre_fatal 2y ago
The translation rate is surprisingly bad.
> Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002667 https://journals.plos.org/plosbiology/article?id=10.1371/jou...
- abdullahkhalids 2y agoThe "badness" of that number depends on the base rate. The base is getting to regulatory approval by doing exploratory studies on humans tissue (you can't ethically do exploratory studies on human subjects). If the base rate is 0.5%, then 5% is an order of magnitude improvement and pretty good. If the base rate is 4%, then 5% is pretty bad. I would suspect that the base rate is far below 0.5%.
- amenhotep 2y agoBut we're not comparing our excitedness about reading results in rats to our excitedness about reading results in human tissue. We're just trying to decide how excited we should be about the rat headlines.