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Do you know similar stuff about dissociatives, like NMDA-antagonists? Are their effects in any way comparable or is it completely different net results?
by Obscurity4340 2y ago
Do you know similar stuff about dissociatives, like NMDA-antagonists? Are their effects in any way comparable or is it completely different net results?
- jklinger410 2y agoI have no experience with those, to be honest. But I feel like they have a similar effect. Considering Ketamine is used for similar purposes.
- willy_k 2y agoIn short, no. I don’t know about their effects on brain connectivity or other imaging characteristics, but the subjective effects are significantly different and the (mental) therapeutic effects come from neuroplasticity being induced, which is independent from NMDA antagonism[0]. This is likely why ketamine (and analogues) stand out as treatments for depression and other conditions. [0] https://www.nature.com/articles/s41380-021-01121-1 https://www.nature.com/articles/s41380-021-01121-1