Of course on a completely different level, but I think this will be similar to how e.g. antibiotics or biologics have played out. First generation has awful sid

Of course on a completely different level, but I think this will be similar to how e.g. antibiotics or biologics have played out. First generation has awful side effects as researchers focus on getting anything to work at all. Then once a certain baseline of efficacy is reached, they can focus on reducing side effects.