6 ms·

Is there anything like this for ovarian cancer? Nearing the end of life for a family member

by cdolan 2y ago

dotcoma 2y ago
Maybe this can help. https://www.clinicalnet.com/ https://www.clinicalnet.com/
melling 2y ago
I’m an amateur but have read a bunch about the new targeted therapies, like immunotherapy. Immunotherapy seems to only work in a small percentage of tumors with a lot of mutations. It’s easier to get your immune system to attack those. There are other targeted therapies depending on the genetic makeup of the tumor. BRAF, RAS, KRAS, NRAS, HER2, BRCA, … Maybe start here. There’s an incredible amount to learn. https://amp.cancer.org/cancer/types/ovarian-cancer/treating/targeted-therapy.html https://amp.cancer.org/cancer/types/ovarian-cancer/treating/... One really interesting advance is histotripsy which uses ultrasound to go after the cancer that has spread to your liver. https://histosonics.com/the-science/ https://histosonics.com/the-science/ Lots of informative YouTube videos. Look for ones by ASCO, Stanford, Mayo,MD Anderson, …
toomuchtodo 2y ago
Are you located anywhere near the University of Texas? There appears to be a protocol combining etigilimab and nivolumab. https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2021-08531 https://www.cancer.gov/research/participate/clinical-trials-... https://www.mdanderson.org/cancerwise/ovarian-cancer-survivor--an-immunotherapy-clinical-trial-saved-my-life.h00-159618645.html https://www.mdanderson.org/cancerwise/ovarian-cancer-survivo... Another potential protocol involves azenosertib in patients with high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. https://www.onclive.com/view/dr-westin-on-early-findings-with-azenosertib-in-high-grade-serous-ovarian-cancer https://www.onclive.com/view/dr-westin-on-early-findings-wit... (not a doctor, not medical advice, just connecting dots, please take citations to a highly competent practitioner in this specific medicine domain such as the oncologist care provider/team of the patient you are advocating for, this is simply due diligence to prevent potential blindspots, we are all just human)
mjfl 2y ago
My condolences... You should consult with their oncologist, but you could ask for Keytruda treatment. You should be aware that the immune response to a late stage cancer that results could also be dangerous, including high fever and delirium... Best wishes to you and your family...
linearrust 2y ago
If there was, your family member's oncologist would have informed your family member of it. Also, keep in mind that this article, like so many such articles, was probably a paid industry advertisement. I'm assuming by this time, everyone is aware of graham's submarine article. Maybe it will change cancer treatment forever, but as far as I know, cancer patients still go through some form of surgery, radiation, chemotherapy, etc.
- el_benhameen 2y ago
  > If there was, your family member's oncologist would have informed your family member of it. I have no insight into the OP’s case in particular, but this is objectively untrue in a large majority of cases. The percentage of oncologists who stay on top of and recommend clinical trials to their patients is in the single digits. One thing I’ve learned from following Jake Seliger’s excellent blog [0] is that cancer patients are often on their own when it comes to researching and applying to clinical trials. [0] https://jakeseliger.com/ https://jakeseliger.com/
  - mlyle 2y ago
    > One thing I’ve learned from following Jake Seliger’s excellent blog [0] is that cancer patients are often on their own when it comes to researching and applying to clinical trials. And, IMO, this mostly makes sense. There's very limited spots and eligibility criteria; we can't throw everyone in a trial. Filtering based on who is most motivated to go through the process makes sense. The opposite, where oncologists enthusiastically convey the news of trials that probably won't work and offer false hope, isn't great. The whole point of the trial is to get to the point where we know we can recommend this for more people.
- ClumsyPilot 2y ago
  > If there was, your family member's oncologist would have informed your family member of it. You faith in the medical profession is wildly excessive. I was just given someone else’s xray and someone else’s IV
- bsder 2y ago
nullserver 2y ago
[flagged]
- staunton 2y ago
  Can you link to any such studies?
  - nullserver 2y ago
    https://x.com/VigilantFox/status/1720857911830736952 https://x.com/VigilantFox/status/1720857911830736952 You’re gonna have to do your own searching. Lots of stories of people that have had success. It is shocking how people here are willing to let millions die rather than consider any alternatives
    - melling 2y ago
      That’s garbage you found on the Internet that simply isn’t true. Dr William Makis isn’t an oncologist either. He seems to be a radiologist. And this isn’t his only conspiracy theory. https://www.reuters.com/article/fact-check/no-evidence-that-80-canadian-doctors-died-from-covid-vaccinations-idUSL1N33K1EM/ https://www.reuters.com/article/fact-check/no-evidence-that-... There are, however, real studies. Perhaps it will be used in the future with other drugs. https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2022-02421 https://www.cancer.gov/research/participate/clinical-trials-...
    - jamiek88 2y ago
      So, no. You can’t. God I despise it when people do this.
    - wnmurphy 2y ago
      Ah yes, "do your own research."
      - cancerhacker 2y ago
        We did! When my oncologist team at UCSC declared my liver mets inoperable, we researched our way to a different group (at Sloan-Kettering) that had success with 75% liver resections and then the two groups worked together. So there is some do your own research that could be valuable - but it’s more along the lines of a second opinion, and there is no magic.
y-curious 2y ago
I actually wrote my thesis on this. Ovarian is very commonly studied for immunotherapy, but there isn't anything out there outside of the clinical research realms. The data is pointing more and more to solid cancers being much less responsive to immunotherapy than blood cancers. Unfortunately, I don't have good news for you here. We are probably 30 years away from having an IT medicine that doctors prescribe regularly. And even then, it will be insanely expensive
- littlestymaar 2y ago
  Since you're knowledgeable in the field, I have a question: what makes immunotherapy more inherently expensive compared to other options?
  - pinewurst 2y ago
    Because each patient’s treatment has to be individually created for them.
    - moshun 2y ago
      This seems like a space ripe for intelligent robotics automation. Detailed, precise and laborious requiring years of not decades of technical expertise.
      - becurious 2y ago
        Look at what Cellares is doing. Building a manufacturing cell called the shuttle.
      - cactusfrog 2y ago
        Biochemical engineering exists as a discipline and focused on “scale up” of production problems like these. Robots are involved, but most of the time the process is modified to a more stable one.
    - mahkeiro 2y ago
      They are many different kind of immunotherapies, not all of them have to be patient specific. For cell or vaccine therapies a lot work is currently done to create "off the shelf" treatment which may ease the issue with car-t treatments.

Is there anything like this for ovarian cancer? Nearing the end of life for a family member

by cdolan 2y ago

Is there anything like this for ovarian cancer? Nearing the end of life for a family member

dotcoma 2y ago

Maybe this can help. https://www.clinicalnet.com/ https://www.clinicalnet.com/

melling 2y ago

I’m an amateur but have read a bunch about the new targeted therapies, like immunotherapy. Immunotherapy seems to only work in a small percentage of tumors with a lot of mutations. It’s easier to get your immune system to attack those. There are other targeted therapies depending on the genetic makeup of the tumor. BRAF, RAS, KRAS, NRAS, HER2, BRCA, … Maybe start here. There’s an incredible amount to learn. https://amp.cancer.org/cancer/types/ovarian-cancer/treating/targeted-therapy.html https://amp.cancer.org/cancer/types/ovarian-cancer/treating/... One really interesting advance is histotripsy which uses ultrasound to go after the cancer that has spread to your liver. https://histosonics.com/the-science/ https://histosonics.com/the-science/ Lots of informative YouTube videos. Look for ones by ASCO, Stanford, Mayo,MD Anderson, …

toomuchtodo 2y ago

Are you located anywhere near the University of Texas? There appears to be a protocol combining etigilimab and nivolumab. https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2021-08531 https://www.cancer.gov/research/participate/clinical-trials-... https://www.mdanderson.org/cancerwise/ovarian-cancer-survivor--an-immunotherapy-clinical-trial-saved-my-life.h00-159618645.html https://www.mdanderson.org/cancerwise/ovarian-cancer-survivo... Another potential protocol involves azenosertib in patients with high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. https://www.onclive.com/view/dr-westin-on-early-findings-with-azenosertib-in-high-grade-serous-ovarian-cancer https://www.onclive.com/view/dr-westin-on-early-findings-wit... (not a doctor, not medical advice, just connecting dots, please take citations to a highly competent practitioner in this specific medicine domain such as the oncologist care provider/team of the patient you are advocating for, this is simply due diligence to prevent potential blindspots, we are all just human)

mjfl 2y ago

My condolences... You should consult with their oncologist, but you could ask for Keytruda treatment. You should be aware that the immune response to a late stage cancer that results could also be dangerous, including high fever and delirium... Best wishes to you and your family...

linearrust 2y ago

If there was, your family member's oncologist would have informed your family member of it. Also, keep in mind that this article, like so many such articles, was probably a paid industry advertisement. I'm assuming by this time, everyone is aware of graham's submarine article. Maybe it will change cancer treatment forever, but as far as I know, cancer patients still go through some form of surgery, radiation, chemotherapy, etc.

el_benhameen 2y ago
> If there was, your family member's oncologist would have informed your family member of it. I have no insight into the OP’s case in particular, but this is objectively untrue in a large majority of cases. The percentage of oncologists who stay on top of and recommend clinical trials to their patients is in the single digits. One thing I’ve learned from following Jake Seliger’s excellent blog [0] is that cancer patients are often on their own when it comes to researching and applying to clinical trials. [0] https://jakeseliger.com/ https://jakeseliger.com/
- mlyle 2y ago
  > One thing I’ve learned from following Jake Seliger’s excellent blog [0] is that cancer patients are often on their own when it comes to researching and applying to clinical trials. And, IMO, this mostly makes sense. There's very limited spots and eligibility criteria; we can't throw everyone in a trial. Filtering based on who is most motivated to go through the process makes sense. The opposite, where oncologists enthusiastically convey the news of trials that probably won't work and offer false hope, isn't great. The whole point of the trial is to get to the point where we know we can recommend this for more people.
ClumsyPilot 2y ago
> If there was, your family member's oncologist would have informed your family member of it. You faith in the medical profession is wildly excessive. I was just given someone else’s xray and someone else’s IV
bsder 2y ago

nullserver 2y ago

[flagged]

staunton 2y ago
Can you link to any such studies?
- nullserver 2y ago
  https://x.com/VigilantFox/status/1720857911830736952 https://x.com/VigilantFox/status/1720857911830736952 You’re gonna have to do your own searching. Lots of stories of people that have had success. It is shocking how people here are willing to let millions die rather than consider any alternatives
  - melling 2y ago
    That’s garbage you found on the Internet that simply isn’t true. Dr William Makis isn’t an oncologist either. He seems to be a radiologist. And this isn’t his only conspiracy theory. https://www.reuters.com/article/fact-check/no-evidence-that-80-canadian-doctors-died-from-covid-vaccinations-idUSL1N33K1EM/ https://www.reuters.com/article/fact-check/no-evidence-that-... There are, however, real studies. Perhaps it will be used in the future with other drugs. https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2022-02421 https://www.cancer.gov/research/participate/clinical-trials-...
  - jamiek88 2y ago
    So, no. You can’t. God I despise it when people do this.
  - wnmurphy 2y ago
    Ah yes, "do your own research."
    - cancerhacker 2y ago
      We did! When my oncologist team at UCSC declared my liver mets inoperable, we researched our way to a different group (at Sloan-Kettering) that had success with 75% liver resections and then the two groups worked together. So there is some do your own research that could be valuable - but it’s more along the lines of a second opinion, and there is no magic.

y-curious 2y ago

I actually wrote my thesis on this. Ovarian is very commonly studied for immunotherapy, but there isn't anything out there outside of the clinical research realms. The data is pointing more and more to solid cancers being much less responsive to immunotherapy than blood cancers. Unfortunately, I don't have good news for you here. We are probably 30 years away from having an IT medicine that doctors prescribe regularly. And even then, it will be insanely expensive

littlestymaar 2y ago
Since you're knowledgeable in the field, I have a question: what makes immunotherapy more inherently expensive compared to other options?
- pinewurst 2y ago
  Because each patient’s treatment has to be individually created for them.
  - moshun 2y ago
    This seems like a space ripe for intelligent robotics automation. Detailed, precise and laborious requiring years of not decades of technical expertise.
    - becurious 2y ago
      Look at what Cellares is doing. Building a manufacturing cell called the shuttle.
    - cactusfrog 2y ago
      Biochemical engineering exists as a discipline and focused on “scale up” of production problems like these. Robots are involved, but most of the time the process is modified to a more stable one.
  - mahkeiro 2y ago
    They are many different kind of immunotherapies, not all of them have to be patient specific. For cell or vaccine therapies a lot work is currently done to create "off the shelf" treatment which may ease the issue with car-t treatments.