I think that's a good metaphor where context is the impact of previous states. Every piece of the system is incredibly dynamic and has an huge degree of nuance

I think that's a good metaphor where context is the impact of previous states. Every piece of the system is incredibly dynamic and has an huge degree of nuance which impacts the computation including within the synapse, the postsynaptic density, and the presynaptic neuron. The amount and content of vesicles as well as location and density of voltage gated calcium channels can change the content and quantity of signal sent. And that's before we talk about all of the other regulatory proteins presynaptically