3 ms·
That feels like deliberately cute wording. What was the similarity vs the starting molecule? I could probably hand pick a few point mutations substituting one s
by 0cf8612b2e1e 2y ago
That feels like deliberately cute wording. What was the similarity vs the starting molecule? I could probably hand pick a few point mutations substituting one small hydrophobic AA for another without impacting function.
- flobosg 2y agoYou’d be surprised by how many failures you get by such an approach. Hydrophobic cores can be easily disrupted by altering some side chain volumes.