Is the overload of presynaptic serotonin receptors that ends up causes endocytosis of those very receptors. The purpose of these receptors is to help regulate v

Is the overload of presynaptic serotonin receptors that ends up causes endocytosis of those very receptors. The purpose of these receptors is to help regulate vesicular release of serotonin into the synapse by shutting down release when too much is detected. Less of those receptors means more serotonin in the synapse after long periods of treatment. The current overall theory (iirc) is that this helps to drive BDNF upregulation which is a neuronal growth factor that helps to drive more dendrite and bouton formation leading to new and more robust network connections