>If the treatment successfully turns off production of endogenous prion protein, then there won’t be any there to convert, and the disease (theoretically) won’t

>If the treatment successfully turns off production of endogenous prion protein, then there won’t be any there to convert, and the disease (theoretically) won’t progress Yeah that's true, but given how ubiquitous PRNP is in mammals, this could also produce some form of memory, cognitive, or other deficit.