Depending on the population and methodology, anywhere from 10-30% of people diagnosed with major depressive disorder are considered to have "treatment-resistant

Depending on the population and methodology, anywhere from 10-30% of people diagnosed with major depressive disorder are considered to have "treatment-resistant" depression, which usually means they've failed to respond to at least two antidepressants despite adequate compliance (exact definitions vary as this is not a separate diagnosis) [1]. [1] https://www.hopkinsmedicine.org/health/conditions-and-diseases/mood-disorders/treatment-resistant-depression https://www.hopkinsmedicine.org/health/conditions-and-diseas...