6 ms·

Let's hope that from eczema to lupus all these mysterious autoimmune diseases would be at least explained if not eradicated.

riley_dog 2y ago
Agreed. I sure would love to eat gluten.
wkcheng 2y ago
I wonder if allergies can eventually be fixed somehow as well. There has to be an immune or autoimmune reason why some people have tons of allergies and other people are perfectly fine.
- theGnuMe 2y ago
  Allergies are caused by an overactive immune system. The way to overcome them is to train the immune system by exposing yourself to low doses of the allergen. Doctors do this and it’s called allergen immunotherapy. Interestingly this has been done since 1911. https://www.nature.com/articles/s41577-022-00786-1 https://www.nature.com/articles/s41577-022-00786-1
  - anonzzzies 2y ago
    I used to be allergic to 100s (I could not even walk 1 meter of certain weeds and I would get blisters etc) of things until I moved away from my country 20+ years ago. I suddenly was allergic (as far as I know still now) to nothing; I accidentally came in contact with some of the worst allergens of old (as I live in nature since then) and they did nothing to our surprised. My wife who was allergic to seafood (passing out to needing epi levels) and that’s gone too, shortly after the move. I don’t know why; our doctor then didn’t know, but we chalked it up to stress; we went from depressing commute ratrace city jobs to sitting in a forest in nature doing whatever we liked. I work more hours now but they are stressless. Don’t know whatever is true, but one mistake I made was not moving earlier.
    - lynguist 2y ago
      From where to where did you move then?
      - anonzzzies 2y ago
        NL -> ES
        emacsen 2y ago
        It sounds like you moved to Stardew Valley.
        anonzzzies 2y ago
        Certainly looks and feels like it
- hanniabu 2y ago
  Largely depends on gut microbiome
hliyan 2y ago
I've had some sort of autoimmune thing hitting me almost every decade of my life (and then clearing up): eczema, asthma, vitiligo and most recently psoriasis. Usually quite mild, but I worry that the next one in the progression will be arthritis. Most doctors' explanations can be summarised into a shrug. Would be a relief to know what's going on in there.
- psychopomp 2y ago
  Autoimmune disorders all have a common root of gut dysfunction. I suffered from chronic inflammation for five years, the ultimate solution was a double capsule probiotic and eating more fiber. Most probiotics have a single capsule that opens in the stomach and all those CFUs are killed by stomach acid.
  - hanniabu 2y ago
    Sad to see you're getting down voted, shows how far behind everyone is
  - xlbuttplug2 2y ago
    Any particular strain/brand that helped for you?
    - psychopomp 2y ago
      I use and recommend Seed https://seed.com https://seed.com
- spondylosaurus 2y ago
  Hey: do you have any stomach problems? Because that was me (up to and including the arthritis part) and then my "IBS" turned out to be Crohn's disease and once I started treating that 90% of my other shit vanished. Things were so bad back then that I was seriously considering a hip replacement to make the pain stop, but today I just hopped off the exercise bike and feel totally fine.
  - 2y ago
alexey-salmin 2y ago
There is a study that claims that genes associated with autoimmune diseases increased survival during the black death epidemic by 40% and frequency of these genes increased a lot in the 14th century Europe [1]. I haven't yet seen independent confirmations but I can imagine that paranoid immune system can be beneficial depending on circumstances. If we eradicate autoimmune diseases then there's a chance we won't survive the next big pandemic. [1] https://www.nih.gov/news-events/nih-research-matters/how-black-death-shaped-human-evolution https://www.nih.gov/news-events/nih-research-matters/how-bla...
- wyldfire 2y ago
  > If we eradicate autoimmune diseases then there's a chance we won't survive the next big pandemic. IMO it seems more likely that we'd find effective treatment which mitigates symptoms of autoimmune disease than a treatment that irreversibly eradicates the disease (including from subsequent generations, even?).

riley_dog 2y ago

Agreed. I sure would love to eat gluten.

wkcheng 2y ago

I wonder if allergies can eventually be fixed somehow as well. There has to be an immune or autoimmune reason why some people have tons of allergies and other people are perfectly fine.

theGnuMe 2y ago
Allergies are caused by an overactive immune system. The way to overcome them is to train the immune system by exposing yourself to low doses of the allergen. Doctors do this and it’s called allergen immunotherapy. Interestingly this has been done since 1911. https://www.nature.com/articles/s41577-022-00786-1 https://www.nature.com/articles/s41577-022-00786-1
- anonzzzies 2y ago
  I used to be allergic to 100s (I could not even walk 1 meter of certain weeds and I would get blisters etc) of things until I moved away from my country 20+ years ago. I suddenly was allergic (as far as I know still now) to nothing; I accidentally came in contact with some of the worst allergens of old (as I live in nature since then) and they did nothing to our surprised. My wife who was allergic to seafood (passing out to needing epi levels) and that’s gone too, shortly after the move. I don’t know why; our doctor then didn’t know, but we chalked it up to stress; we went from depressing commute ratrace city jobs to sitting in a forest in nature doing whatever we liked. I work more hours now but they are stressless. Don’t know whatever is true, but one mistake I made was not moving earlier.
  - lynguist 2y ago
    From where to where did you move then?
    - anonzzzies 2y ago
      NL -> ES
      - emacsen 2y ago
        It sounds like you moved to Stardew Valley.
        anonzzzies 2y ago
        Certainly looks and feels like it
hanniabu 2y ago
Largely depends on gut microbiome

hliyan 2y ago

I've had some sort of autoimmune thing hitting me almost every decade of my life (and then clearing up): eczema, asthma, vitiligo and most recently psoriasis. Usually quite mild, but I worry that the next one in the progression will be arthritis. Most doctors' explanations can be summarised into a shrug. Would be a relief to know what's going on in there.

psychopomp 2y ago
Autoimmune disorders all have a common root of gut dysfunction. I suffered from chronic inflammation for five years, the ultimate solution was a double capsule probiotic and eating more fiber. Most probiotics have a single capsule that opens in the stomach and all those CFUs are killed by stomach acid.
- hanniabu 2y ago
  Sad to see you're getting down voted, shows how far behind everyone is
- xlbuttplug2 2y ago
  Any particular strain/brand that helped for you?
  - psychopomp 2y ago
    I use and recommend Seed https://seed.com https://seed.com
spondylosaurus 2y ago
Hey: do you have any stomach problems? Because that was me (up to and including the arthritis part) and then my "IBS" turned out to be Crohn's disease and once I started treating that 90% of my other shit vanished. Things were so bad back then that I was seriously considering a hip replacement to make the pain stop, but today I just hopped off the exercise bike and feel totally fine.
- 2y ago

alexey-salmin 2y ago

There is a study that claims that genes associated with autoimmune diseases increased survival during the black death epidemic by 40% and frequency of these genes increased a lot in the 14th century Europe [1]. I haven't yet seen independent confirmations but I can imagine that paranoid immune system can be beneficial depending on circumstances. If we eradicate autoimmune diseases then there's a chance we won't survive the next big pandemic. [1] https://www.nih.gov/news-events/nih-research-matters/how-black-death-shaped-human-evolution https://www.nih.gov/news-events/nih-research-matters/how-bla...

wyldfire 2y ago
> If we eradicate autoimmune diseases then there's a chance we won't survive the next big pandemic. IMO it seems more likely that we'd find effective treatment which mitigates symptoms of autoimmune disease than a treatment that irreversibly eradicates the disease (including from subsequent generations, even?).