3 ms·
I've encountered an individual who had fibro, me/cfs, pots diagnosis. Turns out his small nerve fibers were fried by an antibiotic. His skin punch biopsy showed
by avgDev 2y ago
I've encountered an individual who had fibro, me/cfs, pots diagnosis. Turns out his small nerve fibers were fried by an antibiotic. His skin punch biopsy showed reduced fibers. This may not be the case in everyone, but SFN is extremely under diagnosed.
He was a chemist, and he ended up healing all his symptoms with pirenzepine. If I recall correctly they did the skin punch biopsy again and his physician was stunned when they saw regrowth of the fibers.
Today, WinSanTor is in stage 3 trials with their drug. They designed a cream with main ingredient being pirenzepine. They are targeting diabetes but the med appears to work for small nerve fibers as well.
Small nerve fibers control so much that any time people have weird unexplained symptoms it should be explored.
- carynh 2y ago> He was a chemist, and he ended up healing all his symptoms with pirenzepine. As in taking it orally for his SFN? That sounds equally fascinating as it sounds unlikely to me so I'd def love to read a bit more about it!
- sharpshadow 2y agoIndeed Pirenzepine[1] is a muscarinic receptor antagonists. “The muscarinic receptor is a protein involved in the transmission of signals through certain parts of the nervous system, and muscarinic receptor antagonists work to prevent this transmission from occurring.“[2] I could imagine that a let’s say relaxed nervous system recovers better. 1. https://en.m.wikipedia.org/wiki/Pirenzepine https://en.m.wikipedia.org/wiki/Pirenzepine 2. https://en.m.wikipedia.org/wiki/Muscarinic_receptor_antagonists https://en.m.wikipedia.org/wiki/Muscarinic_receptor_antagoni...
- avgDev 2y agoYes, he did take an oral dose, I believe it was higher than recommended dose, so some risk involved. I don't really see any studies on oral administration, but the new cream showed systemic relief.