We are complex adaptive organisms embedded in a dynamic environment; hence the environment changes us in response to which we change the environment and the cyc

We are complex adaptive organisms embedded in a dynamic environment; hence the environment changes us in response to which we change the environment and the cycle continues. In the case of social-isolation it seems to me this cycle becomes a downward spiral leading to actual biological changes in ourselves which may also be exacerbated by genetic and/or preexisting factors. Google search brings up a bunch of papers/studies but i can find nothing comprehensive which looks at all aspects. Note that there is some cure (but obviously not 100%) and seems to involve social,psychological,medicinal approaches used together under competent supervision. References: 1) Finding the Biological Roots for the Pathological Social Withdrawal Known as ‘Hikikomori’ - https://neurosciencenews.com/hikikomori-social-withdrawal-biomarker-20722/ https://neurosciencenews.com/hikikomori-social-withdrawal-bi... 2) Autism Spectrum, Hikikomori Syndrome and Internet Gaming Disorder: Is There a Link? - https://www.mdpi.com/2076-3425/13/7/1116 https://www.mdpi.com/2076-3425/13/7/1116 3) Hikikomori: A Scientometric Review of 20 Years of Research - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177810/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177810/