This is very interesting for me to read -- my experience was the opposite: dihiydroergotamine was always preposterously expensive (hundreds of dollars for one d

This is very interesting for me to read -- my experience was the opposite: dihiydroergotamine was always preposterously expensive (hundreds of dollars for one dose); the history of it was like one of those fascinating novels with a disastrous chain of unintended consequences. It's basically a fungus, used forever, it should be trivial. It predated the FDA, and therein lay the bizarre economic and regulatory paradox: it was grandfathered in, in a way, but the delivery mechanism (a nasal spray) was a later invention that went through the full clinical research gamut. There's no money in the drug to do clinical trials, so it fell into this weird gray area. I wish I could find the article from when I looked into it, presumably some plaintive search at the time, "why is Migranal so expensive?"