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Also what other structures are left out because they haven't been discovered because staining techniques don't make them visible? The dark matter of biology, i
by rapjr9 2y ago
Also what other structures are left out because they haven't been discovered because staining techniques don't make them visible? The dark matter of biology, is anyone even trying to look for such things? Though you would think electron microscopy would reveal everything.
Everything I read in the article makes it sound like vaults are part of the immune system, but nobody understands how they work. It seems really weird that there can be a major structure in a cell "thousands in some cells" and research has not found what role they play after decades. Probably a noble prize waiting here.
They knocked out the vaults in experiments, but did they then challenge the vault-deprived mice with viruses or did the mice live in an isolated environment to keep them away from confounders? If you remove part of the immune system and there are no immune challenges then it would seem like that part of the system does nothing. The environment matters a lot in such experiments.
- Bluestein 2y ago>;they haven't been discovered because staining techniques don't make them visible? To that point, there was a recent article here (that, sadly went mostly unnoticed), about Polish scientists finding novel applicability of gold particles of a certain shape in cancer treatment ... ... but crucial and structural to their findings (and salient about the article, I thought) was the use of a novel kind of microscopy and procedure that enabled the discovery itself. Worth reading ...
- Bluestein 2y agoFound the article. Interesting: - https://news.ycombinator.com/item?id=40819854 https://news.ycombinator.com/item?id=40819854
- ahazred8ta 2y agoHarold Edgerton was a mechanical engineer trying to analyze a vibrating drive shaft. He finally took strobe photos of it vibrating. His advisor told him, never mind the drive shaft, start working on strobe photography.