DeepFilterNet doesn't use a second microphone but it does do an absurdly good job of removing not-speech from inputs in realtime. Check out the demo video linke

DeepFilterNet doesn't use a second microphone but it does do an absurdly good job of removing not-speech from inputs in realtime. Check out the demo video linked in the README. iirc they demonstrate removing guitar sounds and even a vacuum cleaner. It does take some technical elbow grease to integrate but I've used it in calls and while gaming on Linux via Pipewire to great effect. https://github.com/Rikorose/DeepFilterNet https://github.com/Rikorose/DeepFilterNet