> What do you think the mechanism behind this is Estrogen in the brain is neuro-protective and neuro-trophic. The primary source of estrogen in the brain for

> What do you think the mechanism behind this is Estrogen in the brain is neuro-protective and neuro-trophic. The primary source of estrogen in the brain for men is testosterone converted via aromatase. However, that's speculative. I found no significant studies on point, notwithstanding physician interest. Because some men seek out testosterone, some doctors might be quick to offer it off-label for other conditions.