4 ms·

GLP-1 gene therapy reduces weight by 22% & positive results of long-term therapy

• pizza 2y ago
  (in mice)
  • viraptor 2y ago
    Usually yes, but here it's the same target as for the Ozempic drug which is already widely used by people. As far as I understand, there's no reason to suspect that it wouldn't work the same.
    • yawpitch 2y ago
      Ok, so now the question becomes what’s 4 mouse weeks in human decades?
      • viraptor 2y ago
        Why 4 weeks? The mice were followed for 8 weeks in total and after 8 weeks there was no regression after the gene therapy.
        • yawpitch 2y ago
          The human studies they’re proceeding towards are both related to the Group 2B mice, those that were on semaglutide until discontinuation at 4 weeks and then were given a single dose of this new gene therapy. At 8 weeks those mice which had now been exposed to this therapy at 4 weeks still maintained the weight loss that had initially been achieved on semaglutide… this is significant because there’s a huge cohort of humans out there currently on semaglutide who are (based on this and other studies) on a collision course with regaining all their lost weight very shortly after (inevitably, due to either cost, side effects, or attenuation) discontinuing semaglutide. So the only thing that really matters here is how does 4 weeks of post-semaglutide weight loss maintenance in mice equate to such maintenance in humans. There might eventually be good reason to look at the Group 1 results as something to try and replicate in humans, but the company involved doesn’t seem to be going there just yet.