4 ms·
The actual study says the opposite: >"It is encouraging, however, that long- term TAC treatment was well tolerated without any overt or his- tological adverse
by RobotToaster 2y ago
The actual study says the opposite:
>"It is encouraging, however, that long-
term TAC treatment was well tolerated without any overt or his-
tological adverse effects including carcinogenesis. Nonetheless,
additional safety studies in non-human primates are warranted.
Along these lines, it is worth noting that TAC may reduce cancer
incidence, given that insufficient telomerase resulting in telomere
dysfunction coupled with loss of p53-dependent DNA check-
point control is a major driver of chromosomal instability and
cancer genesis in the aged. 53 Correspondingly, TERT reactiva-
tion in aged inducible-TERT mice was shown to reverse aging
phenotypes without causing an increase in cancer."
https://hub.libstc.cc/10.1016/j.cell.2024.05.048.pdf https://hub.libstc.cc/10.1016/j.cell.2024.05.048.pdf