4 ms·

I'm 254 days into switching to a ketogenic diet (complete with at home instant ketone finger prick blood tests using the very affordable keto mojo), and can't b

• waynenilsen 2y ago
  How much protein can you eat before getting kicked out of ketosis?
  • chollida1 2y ago
    why would protein kick you out of ketosis, on Keto alot of people, especially athletes load up on as much protein as they can and use fat to get the rest of their calories.
    • silverquiet 2y ago
      I was under the impression that the body can synthesize sugars if given enough protein.
      • oarfish 2y ago
        I think you can make 150g or so of glucose (?) yourself, but whether thats enough might depend on what you are doing in life i think.
    • xcskier56 2y ago
      My biochem is a little rusty but basically your body can create glucose (carbs) from amino acids (proteins) in a process called gluconeogenesis. Because your body will preferentially use glucose over fat and ketones for fuel, it will prioritize this pathway and turn down/off the one that produces ketones... hence dropping you out of ketosis.
      • DougWebb 2y ago
        Your body doesn't prefer glucose over fat. Too much glucose is toxic, so your body will focus on reducing it first. Too little is also dangerous so your body will make some from protein if necessary. But only as much as it needs. Fat adaptation is about shifting your hormonal balance and response to retrain your body to maintain a lower level of glucose, and to retrain your cravings and hunger.
        • xcskier56 2y ago
          I'm not talking at the higher organism level, I'm talking at the very low-level chemistry in mitochondria. Glucose is "easier" to produce energy out of and so that happens preferentially from a chemistry perspective. Your body also needs a minimum level of glucose to survive. When there isn't enough glycogen, the chemical balances in the mitochondria change and the liver mitochondria will produce glucose from whatever they have. This isn't a "decision" just the relative amounts of the chemicals change leading to one chemical pathway becoming more likely compared to another. This is all mediated by the random collisions of molecules in your cells. If you have a lot less of one molecule compared to another, the frequency that molecules find each other to do one thing v/s the other will change leading to different chemical pathways becoming more or less active. There are many routes for your body to produce glucose. It is "easier" for your body to produce it from gluconegenic amino acids (not all amino acids can be used to produce glucose) than it is from fatty acids. It's the process of converting fatty acids into glucose that generates ketones. So when you have excess amino acids that can be turned into glucose, the chemistry will prefer this pathway over breaking down fat into glucose and this will lead to lower ketone production overall and kick you out of ketosis. (I think I've gotten the gist of this right but any biochem experts feel free to correct me)
      • jddj 2y ago
        I can't speak to whether or not it's true, but I heard the response to this question being that this process is quite precise, and functions specifically to meet the brain's glucose needs and nothing more.
    • oarfish 2y ago
      As an athlete you shouldn't avoid carbs, unless you are ok with impairing your athletic performance.
    • swiftcoder 2y ago
      > on Keto alot of people, especially athletes load up on as much protein as they can This only works because athletes tend to have pretty insane protein (and calorie!) demands. If you as a regular, non-athlete person load up on protein (while neglecting to consume sufficient fat), your body will be forced to convert the protein into glucose, and you'll fall right out of ketosis
      • KptMarchewa 2y ago
        First of all, it's not a binary process.
  • heelix 2y ago
    Carbs are what kick you out of ketosis. Protein and fats won't, but they have other issues. (Fiber can be a real challenge)
• malux85 2y ago
  Me too, about same time as you. Life-changing productivity increase and focus/deep work extension!
• chollida1 2y ago
  My biggest problem with Keto is that is that one bad meal and your out. I found it was just such a pain in the as for other as much as it was for me. Every meal at someone elses house I had to make my specific nutritional requirements available to the host, which then puts them out.
  • cm2187 2y ago
    Same thing with intermittent fasting. One deviation and the appetite comes back with a vengeance and you have to restart from scratch the process of getting used to fasting (which is the hard part, the appetite is what makes the caveman go out chase the mammoth, it's a strong force). Experimenting with Mounjaro right now + intermittent fasting. So far so good, but only one week into it. I am hoping to use it as a guardrail in case of any accidental deviation.
    • ImHereToVote 2y ago
      Just be hungry dude. It's not hard. I notice I'm much more productive while I'm hungry. Also food is so much better when you have been actually hungry for a while.
    • KptMarchewa 2y ago
      Not from scratch. It's a setback but you don't go to start line.
      • cm2187 2y ago
        In term of getting your appettite used to intermittent fasting? Yes pretty much you do.
        • KptMarchewa 2y ago
          Not really. It takes maybe 2-3 days to go back compared to 2+ weeks initially.
        • deleted 2y ago
          [deleted]
• medler 2y ago
  My problem with keto is that most people on it eat so much saturated fat that their cholesterol goes through the roof, and that’s really bad for cardiovascular health. (Keto communities deal with this by preaching an anti-science, cholesterol-denialist dogma, but that dogma has always been driven by wishful thinking).
  • breck 2y ago
    > My problem with keto is that most people on it eat so much saturated fat that their cholesterol goes through the roof Dataset needed
    • medler 2y ago
      Here are a couple of studies: https://www.med.ubc.ca/news/popular-keto-diet-may-be-linked-to-higher-risk-of-heart-disease-cardiac-events/ https://www.med.ubc.ca/news/popular-keto-diet-may-be-linked-... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121782/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121782/
      • breck 2y ago
        Ok, thanks for the links. I had time to read the first study you shared. Here is the link to the actual study: https://www.sciencedirect.com/science/article/pii/S2772963X24001066 https://www.sciencedirect.com/science/article/pii/S2772963X2... Positives: - PDF is available! - Nice formatting - Very well written, very clear what they did Negatives: - Not an experiment. An observational study. - If I'm reading correctly, they classified someone's diet mostly based on 1 single prior 24 hour food questionnaire. This is a bit...weak. - The LCHF cohort has significant pre-existing conditions (which they do correct for, but their headline is about the non-corrected number) - They define LCHF diets as being <100g of carbs a day, and define VLC diets as being <50g a day, but do NOT publish any results for the VLC cohort. Why not? - They then do NOT publish their data! - BUT if you dig into their supplementary tables, they DO report that VLCs have lower rates of ASCVD than LCHF. - They have conflicts of interest: "Dr Brunham has served on advisory boards for Amgen, Novartis, HLS Therapeutics, and Ultragenyx. Dr Iatan has served on advisory boards for Novartis and HLS Therapeutics and receiving honoraria from Novartis and Sanofi. " Anyway, I give that one a C-. Well executed, but looks like their hands are tied. I would not bet on its associations to reproduce in an experiment.