Be careful because there exists significant evidence against the ketogenic diet. For example: Ketogenic diets inhibit mitochondrial biogenesis and induce cardi

Be careful because there exists significant evidence against the ketogenic diet. For example: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis (2021) (PMID: 33558457) > increased β-OHB levels and SIRT7 expression, decreased mitochondrial biogenesis, and increased cardiac fibrosis were detected in human atrial fibrillation heart tissues. Our results highlighted the unknown detrimental effects of KDs Ketogenic diet induces p53-dependent cellular senescence in multiple organs (2024) (PMID: 38758782) > Mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart and kidney. This effect is mediated through adenosine monophosphate-activated protein kinase (AMPK) and inactivation of mouse double minute 2 (MDM2) by caspase-2, leading to p53 accumulation and p21 induction. This was established using p53 and caspase-2 knockout mice and inhibitors to AMPK, p21, and caspase-2. In addition, senescence-associated secretory phenotype biomarkers were elevated in serum from mice on a KD and in plasma samples from patients on a KD clinical trial. Cellular senescence was eliminated by a senolytic and prevented by an intermittent KD. As per PMC11100565, a cycled KD avoids the senescence issue: > Both an alternate-day and an alternate-week IKD have been reported to improve health parameters over a continuous KD in different murine models (10, 64), while a third study using a 3-day/week IKD reported attenuated improvements relative to continuous KD (74).