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I like to think about it this way: I cannot name another family that helped introduce a nationwide need for a completely new type of first aid, that being nalo

I like to think about it this way: I cannot name another family that helped introduce a nationwide need for a completely new type of first aid, that being naloxone. It's not just ambulances; it's in police cars, pharmacies, libraries, schools, and workplaces. A complete deployment throughout the third-largest society in the world, in less than ten years, because of the frequency of overdose. Just consider that for a moment.

walterbell 2y ago
Gabapentoids (e.g. pregabalin, gabapentin) need similar scrutiny, as they are routinely prescribed to millions of elderly people, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265598/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265598/ > gabapentinoids are increasingly being used for off-label conditions despite the lack of evidence. Prescription rates for off-label conditions have overtaken that for on-label use. Similarly, the use of gabapentinoids in the perioperative period is now embedded in clinical practice despite conflicting evidence. This article summarises the risks associated with this increasing use. There is increasing evidence of the potential to cause harm in vulnerable populations such as the elderly and increasing prevalence of abuse. The risk of respiratory depression in combination with opioids is of particular concern in the context of the current opioid crisis.