Having to route all of your communications through a relay, having to explicitly build out backups to your backups for comms rather than being able to look up w

Having to route all of your communications through a relay, having to explicitly build out backups to your backups for comms rather than being able to look up with your instruments, a longer delay requiring more autonomy on the lunar surface, more radiation, more micrometeorite impacts, rougher terrain, other things.