Epigenetic modifications, such as methylation, are made to DNA by specific proteins. These modifications alter the transcription process from DNA to RNA, which

Epigenetic modifications, such as methylation, are made to DNA by specific proteins. These modifications alter the transcription process from DNA to RNA, which in turn affects protein expression. This includes the expression of the proteins responsible for epigenetic changes themselves. In essence, the proteins that modify DNA also control the expression of their own building instructions through a feedback loop. I guess that feels a bit like a von neumann machine to me, but I'm not sure the analogy is super helpful.